Step 1: Formulating the Question
With clinical cases, there is often a barrage of details to digest. To effectively search EBP resources, you first need to decide what details are important to the question at hand so you can formulate the question.
A well-built clinical question includes the following components:
- The patient’s disorder or disease
- The intervention or finding under review
- A comparison intervention (if applicable—not always present)
- The outcome.
The acronym PICO assists in remembering the steps (P, patient or problem; I, intervention; C, comparison intervention; O, outcomes).

